The Science Behind Sight Guard: Research Supported Ingredients for Eye Health

Introduction: What Really Supports Long Term Eye Health?

When people think about supporting their eyes, they often picture blue light glasses or taking more screen breaks. But at the cellular level, the health of your eyes depends on energy production, antioxidant support, and a steady supply of protective nutrients. As we age, these systems naturally become less efficient.

Sight Guard was created to make it easier for people to give their eyes daily nutritional support with evidence based ingredients. This article breaks down the science behind those ingredients and what peer reviewed research says about each one.

This article is educational and not medical advice.

What Is Sight Guard?

Sight Guard is a daily eye health supplement developed by Nadefense using ingredients studied for mitochondrial support, antioxidant activity, and retinal cell function. The formula includes:

• Nicotinamide riboside (NR) 300 mg
• Calcium pyruvate 400 mg
• Coenzyme Q10 (CoQ10) 100 mg
• Ginkgo biloba extract 60 mg
• Lutein 10 mg

Its goal is simple: support ocular energy metabolism, help protect healthy retinal cells, and promote long term vision wellness in people focused on maintaining their eye health.

Ingredient by Ingredient: What the Research Shows

1. Lutein: The Most Established Eye Health Nutrient

Primary benefits supported by research: Helps maintain macular pigment density, supports retinal antioxidant activity, and plays a role in healthy aging of the macula.

The best studied ingredient in Sight Guard is lutein. It is found naturally in leafy greens and is concentrated in the macula, where it filters high energy blue light and supports antioxidant defenses.

Key Study: AREDS2 Trial

Citation: AREDS2 Research Group, JAMA, 2013. DOI: 10.1001/jama.2013.4997

Dose Studied: Lutein 10 mg + Zeaxanthin 2 mg

The AREDS2 trial found that lutein and zeaxanthin improved macular pigment optical density and reduced risk of progression in people with intermediate age related macular degeneration. Sight Guard contains the same 10 mg lutein dose used in AREDS2.

How lutein supports ocular health:

• Helps maintain the protective yellow pigment in the macula
• Filters blue light
• Supports antioxidant defenses in retinal tissues

2. Nicotinamide Riboside (NR): A Modern Approach to Cellular Energy

NR is a precursor to NAD+, a molecule essential for energy production in retinal ganglion cells. Interest in NAD+ support has grown due to early clinical research exploring whether certain NAD precursors can support inner retinal function.

What clinical trials actually used

Human glaucoma trials used nicotinamide (NAM), not NR. Doses ranged from 1,500 to 3,000 mg per day.

Key Study: De Moraes et al., JAMA Ophthalmology, 2022 (DOI: 10.1001/jamaophthalmol.2021.4576)

Outcome: Improvement in visual field test points when combining high dose nicotinamide and pyruvate.

3. Calcium Pyruvate: A Partner in Cellular Energy

Pyruvate supports mitochondrial energy production. In the glaucoma phase 2 trial, pyruvate was studied at 1,500 to 3,000 mg and always paired with high dose nicotinamide.

Sight Guard contains 400 mg calcium pyruvate.

Pyruvate is of interest due to its roles in cell metabolism, antioxidant recycling, and NAD+/NADH balance.

4. Coenzyme Q10: Antioxidant Support for Mitochondria

CoQ10 is essential for mitochondrial energy transfer. CoQ10 studies have shown improvements in certain measures of retinal function.

Sight Guard uses 100 mg CoQ10 to help support general mitochondrial and antioxidant activity.

5. Ginkgo Biloba: Circulatory and Antioxidant Support

Ginkgo biloba has been studied for its potential to support ocular blood flow and antioxidant activity.

Key Study: Quaranta et al., Ophthalmology, 2003

Dose Studied: 40 mg three times daily (120 mg)

Outcome: Some improvement in visual field performance in people with normal tension glaucoma.

Sight Guard contains 60 mg, which is half the common clinical dose. Results in studies have been mixed, and ginkgo may interact with anticoagulants. Users should speak with a doctor if they take blood thinners.

How These Ingredients Work Together

• Antioxidant Support: Lutein, ginkgo, and CoQ10 each support antioxidant activity in different ways.
• Cellular Energy: NR and pyruvate supply substrates that support healthy NAD+ levels and mitochondrial function.
• Aging Eyes: Ingredients like lutein and ginkgo are commonly studied in age related eye changes.

Research on nicotinamide and pyruvate used high clinical doses that differ from the levels in Sight Guard. Sight Guard does not claim to replicate those results.

Conclusion: Thoughtful Support for Daily Eye Wellness

Sight Guard brings together nutrients that support the cellular environment of the eye, particularly in areas related to antioxidant protection and mitochondrial health. If you want to be proactive about supporting long term eye wellness, Sight Guard can be a helpful daily addition to a balanced lifestyle. Always talk with your eye care provider about what is right for you.